Assessment of immunological mechanism in infertility of the rat after experimental testicular torsion.

Autor: Merimsky, E., Orni-Wasserlauf, R., Yust, I.
Zdroj: Urological Research; Jul1984, Vol. 12 Issue 3, p179-182, 4p
Abstrakt: A necrotic torted testis left in the scrotum affects the contralateral testis, resulting in depressed fertility. It was suggested that testicular torsion provoked a systemic response of an immunologic nature. In order to prove this theory, 56 rats were operated. Ten had a sham operation, in 17 a testis was torted and excised after 24 h, and in 29 a testis was torted and excised after 24 h, and in 29 a testis was torted but left in situ till the sacrifice. Antisperm-antibodies were not found in any phase of the experiment in the sham group. Using indirect immunofluorescence, antisperm-antibodies were found in the sera of 8/17 rats of the orchiectomy group and in 24/29 of the detorted group. In the direct immunofluorescence study, all the antibodies were localized in the tail of the spermatozoid. The antisperm-antibodies dissappeared after 3 to 6 months. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index