| Autor: |
Yamage, M., Evans, C. |
| Zdroj: |
Experientia; Dec1989, Vol. 45 Issue 11/12, p1129-1131, 3p |
| Abstrakt: |
Lanthanide ions (Ln) inhibited the proliferative response of human lymphocytes to various polyclonal mitogens and the 'purified protein derivative' (PPD) of the tuberculin antigen. Of the four Ln ions tested lanthanum (La) was the strongest inhibitor; erbium (Er) and lutetium (Lu) were only weakly active, while samarium (Sm) had intermediate potency. At a concentration of 1 mM, La almost completely inhibited the uptake of [H]-thymidine by lymphocytes exposed to mitogenic agents. Trypan blue exclusion tests confirmed that the La ions were not toxic. These findings may bear upon the reported anti-inflammatory properties of the lanthanides. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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