| Autor: |
Kögl, F., Cox, H., Salemink, C. |
| Zdroj: |
Experientia; Apr1957, Vol. 13 Issue 4, p137-138, 2p |
| Abstrakt: |
A recent investigation of Kögl, Salemink, Schouten and Jellinek established the constitution of muscarin as the quaternary trimethyl-ammonium salt of 2-methyl-3-hydroxy-5- (amino - methyl) - tetrahydrofuran. Moreover the X-ray analysis elucidated the complete stereochemical configuration of the alkaloid. There are various possibilities for a synthetic approach. The present communication gives a preliminary description of a synthesis which started from α-acetyl- δ-chloro- γ-valerolactone, leading to a mixture of muscarin and its stereochemical isomers. The synthetic product gives the same R-value and a very similar infrared spectrum. The pharmacological activity on the frog heart is about one third of that of the natural alkaloid. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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