| Autor: |
Oliveira, Ana Paula, Faveri, Marcelo, Gursky, Lauren Christine, Mestnik, Maria Josefa, Feres, Magda, Haffajee, Anne D., Socransky, Sigmund S., Teles, Ricardo Palmier |
| Předmět: |
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| Zdroj: |
Journal of Clinical Periodontology; Mar2012, Vol. 39 Issue 3, p295-302, 8p, 4 Charts, 1 Graph |
| Abstrakt: |
Aim To examine changes in levels of gingival crevicular fluid ( GCF) cytokines, after periodontal therapy of generalized aggressive periodontitis ( GAgP). Materials and Methods Twenty-five periodontally healthy and 24 GAgP subjects had periodontal clinical parameters measured and gingival crevicular fluid ( GCF) samples collected from up to 14 sites/subject. GCF samples were analysed using multiplex bead immunoassay for: GM- CSF, IFN-γ, IL-10, IL-1β, IL-2, IL-6 and TNF-α. Aggressive periodontitis subjects were randomly assigned to either scaling and root planing ( SRP) alone or SRP plus systemic amoxicillin (500 mg) and metronidazole (400 mg) 3 times a day for 14 days. Clinical parameters and GCF cytokines were re-measured 6 months after treatment. Differences over time were analysed using the Wilcoxon test and between groups using the Mann- Whitney test. Results Significant reductions in GCF GM- CSF, IL-1β and the ratio IL-1β/ IL-10 and increases in GCF IL-6 were detected after therapy. The mean change in GCF cytokines did not differ significantly between groups. Conclusions Periodontal therapy improved GCF cytokine profiles by lowering IL-1β and increasing IL-10 levels. The reduction in GCF GM- CSF after therapy implicates this cytokine in the pathogenesis of GAgP. There was no difference between therapies in changes of GCF cytokines. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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