| Autor: |
Tomonari, Kyuhei, Fairchild, Sue |
| Zdroj: |
Immunogenetics; 1992, Vol. 36 Issue 4, p230-237, 8p |
| Abstrakt: |
Tcrb-V6 T cells are deleted by an endogenous superantigen probably encoded by a mouse mammary tumor provirus ( Mtv), Mtv-7, in association with major histocompatibility complex (MHC) class II molecules. In contrast, Tcrb-V6CD4 T cells are positively selected by MHC class II E molecules in Mtv-7 mice. We have examined the levels of Tcrb-V6CD4 and Tcrb-V6CD8 T cells from six combinations of backcross mice. In this paper we show that: 1) Tcrb-V6CD8 T cells can be positively selected by MHC class I molecules; 2) MHC class II A molecules can also influence the levels of Tcrb-V6CD4 T cells; 3) Mtv-7 NZW mice have a new Mtv, Mtv-44, which co-segregates with a gene encoding the partial deletion ligand for Tcrb-V6 T cells; 4) the remaining Tcrb-V6 T cells from mice with partial deletion of these T cells appear not to be anergized in the periphery. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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