| Autor: |
Gibson, David, Maclean, Sheila, Cherry, Marianna |
| Zdroj: |
Immunogenetics; 1983, Vol. 18 Issue 2, p111-116, 6p |
| Abstrakt: |
Recombination has been detected for the first time between chromosome 6 loci controlling kappa chain expression in normal mouse serum immunoglobulin and the Lyt-3 locus. The recombination event occurred at the 26th or 27th backcross generation during the derivation of the Lyt-2, Lyt-3-congenic line B6.PL(85NS). The line is now homozygous for the Lyt-2, Lyt-3 allele(s) at N30F13 and homozygous animals express the Igk-Ef1 allele derived from C57BL/6. The frequency of recombination has been estimated to be 0.30% based on the present results and previous studies in which no recombination was detected. The results rule out the hypothesis that the Lyt-3 locus itself controls the light chain phenotype observed in normal serum immunoglobulin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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