Anti H-2D alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2 T lymphocytes is associated with H-2D.

Autor: Pfizenmaier, Klaus, Jung, Hartmut, Kurrle, Roland, Röllinghoff, Martin, Wagner, Hermann
Zdroj: Immunogenetics; 1980, Vol. 10 Issue 1-4, p395-404, 10p
Abstrakt: Herpes-simplex-virus (HSV) specific, H-2-restricted, immune cytotoxic T lymphocytes also lyse noninfected H-2 target cells. Genetic mapping studies revealed that HSV-specific D-restricted CTL cross-react with allogeneic targets expressing D alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. The data give an example of where the phenomenon of H-2-restricted versus nonrestricted responsiveness is not due to distinct subsets of T cells but solely depends on the antigenic determinants recognized. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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