Lagomorph-constant region IgG allotypes: Shared e determinants in Ochotona sp.

Autor: Cazenave, Pierre-André, Brézin, Colette, Puget, Alain, Mandy, William
Zdroj: Immunogenetics; 1977, Vol. 4 Issue 1, p489-498, 10p
Abstrakt: The search for C γ allotypes as defined by the markers common to domestic rabbits ( Oryctolagus) was extended to additional lagomorphs of the families Leporidae and Ochotonidae. None of the Ochotona sera obtained from Afghanistan and Iran ( Ochotona rufescens) exhibited the d11, d12, or e14 allotypes. The e15 marker was detected only by radioimmune binding assays. Comparative inhibition of binding assays revealed similarities with other lagomorphs with respect to the e15i determinant. As in some variants of hare e15 markers, the e15j determinant is absent in Ochotona. The results provided a revised phylogenetic scheme for the evolution of the C γ gene on the basis of the e-series allotypes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index