The genetic control of natural killer cell activity and its association with in vivo resistance against a moloney lymphoma isograft.

Autor: Petrányi, Gyözö, Kiessling, Rolf, Povey, Susan, Klein, George, Herzenberg, Leonard, Wigzell, Hans
Zdroj: Immunogenetics; 1976, Vol. 3 Issue 1, p15-28, 14p
Abstrakt: Spleens of normal young mice of certain strains contain lymphocytes that can kill strain A-derived YAC-1 lymphoma cells in aCr release cytotoxic assay in vitro. We have previously classified mouse genotypes as high or low reactors, according to their responses in this test. In vivo resistance to small numbers of YAC ascites lymphoma cells is correlated with in vitro cytolytic activity. In vitro and in vivo tests were carried out on the same individual (A x C57BL)F x A backcross mice. Natural in vitro killer cell activity appeared to be under polygenic control, including a strong H-2-linked factor. No linkage was found with five different isozyme loci, with the Ig-l locus or with C5 serum activity. Also in vivo resistance showed strong linkage with the H-2 complex. In (A x CBA)F x A backcross mice, a weak linkage was found with the coat color locus C. There was a correlation between in vitro killer activity and in vivo resistance in the same backcross mice. In vivo resistance was particularly strong in mice that combined the H-2-linked resistance factor with a high cytolytic activity in vitro. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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