Changes of NMDA receptor binding in spontaneously epileptic rat and parent strains.

Autor: Mitsuyoshi, Izuru, Ito, Masatoshi, Shirasaka, Yukiyoshi, Mikawa, Haruki, Serikawa, Tadao, Yamada, Junzo
Zdroj: Neurochemical Research; Nov1993, Vol. 18 Issue 11, p1169-1173, 5p
Abstrakt: We measured the binding of [H]3-[(±)2-carboxypiperazin-4-yl]propyl-1-phosphonic acid ([H]CPP), a competitive ligand for N-methyl- d-aspartate (NMDA) receptors, in double mutant spontaneously epileptic rats (SER: zi/zi, tm/tm) and their parent strains, zitter rats, and tremor rats, and WTC rats (control rats from tremor rats derived from Kyoto:Wistar rats) before and after the onset of seizures in tremor rats and SER. Significantly lower [H]CPP binding receptor density (B) was found in the cortex of SER and zitter rats at 12-15 weeks of age than in that of WTC rats and tremor rats, and at 4 weeks of age the Bmax in zitter rats was lower than that in the other strains. The reduction of Bmax in SER at 12-15 weeks of age may reflect a down regulation of NMDA receptors due to repetitive tonic seizures in SER. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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