| Autor: |
Meldrum, Michael, Glenton, Pat, Dawson, Ralph |
| Zdroj: |
Neurochemical Research; Feb1992, Vol. 17 Issue 2, p151-156, 6p |
| Abstrakt: |
Alterations in glutamate content and uptake have been reported to occur in aged animals. The present studies used [H] d-Aspartic acid ([H]-D-ASP) release as a marker for glutamate neurotransmission. Frequency dependent [H]-D-ASP release was measured in adult (8 month) and aged (28-30 month) Fischer 344 rats. Relatively high stimulation frequencies (>10 Hz) were required to induce [H]-D-ASP release in both adult and aged F344 rats in temporal cortex and hippocampus. In both brain areas aged animals showed significantly more [H]-D-ASP release than adult animals Kainic acid 1 mM failed to induce the release of [H]-D-ASP in either temporal cortex or hippocampus. Omega conotoxin GVIA (5×10M) a N and L type voltage sensitive calcium channel antagonist failed to inhibit [H]-D-ASP stimulated release. These results demonstrate an increase in [H]-D-ASP release in aged compared to adult F344 rats. The data also suggest a novel calcium channel may be involved in [H]-D-ASP release. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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