| Autor: |
Ledig, M., Tholey, G., Megias-Megias, L., Kopp, P., Wedler, F. |
| Zdroj: |
Neurochemical Research; May1991, Vol. 16 Issue 5, p591-596, 6p |
| Abstrakt: |
Manganese is essential for normal development and activity of the nervous tissue. Mn ions are involved in protein synthesis and may prevent free radical damage. Since it is now established that alcohol degradation may produce free radicals, we studied the effect of Mn on ethanol induced alterations using cultured nerve cells as an experimental model of the central nervous system. Neurons and glial cells were cultured from rat brain cortex; a tumoral rat glial cell line (C6) was also examined. We measured enzymatic markers of nerve cell maturation (enolase, glutamine synthetase) and superoxide dismutase, a scavenger of free radicals; all these enzymes being activated by Mn ions. Only for the glial cell types an alcohol antagonizing effect was found when Mn was combined with ethanol. Neurons were not sensitive to that Mn effect. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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