| Autor: |
Ito, Masatoshi, Tsuda, Hideo, Oguro, Katsuhiko, Mutoh, Kozo, Shiraishi, Hideyuki, Shirasaka, Yukiyoshi, Mikawa, Haruki |
| Zdroj: |
Neurochemical Research; Sep1990, Vol. 15 Issue 9, p933-936, 4p |
| Abstrakt: |
GABA-gated chloride ion influx was measured in brain 'microsac' preparations of epileptic El mice. There was significantly greater sensitivity to GABA in stimulated El mice (which had 14-18 convulsions induced at weekly intervals) than in unstimulated El mice (which had not experienced convulsions) or ddY mice. GABA-gated chloride ion influx was significantly decreased 20 min after a single convulsion, and returned to the preconvulsion level 60 min after a convulsion. These findings suggest that the functional state of GABA-gated chloride channel in El mice is changed secondarily by single or repeated convulsions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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