| Autor: |
Jaffer, Abdullah, Searson, Anita, Russell, Vivienne, Taljaard, Joshua |
| Zdroj: |
Neurochemical Research; Jan1990, Vol. 15 Issue 1, p13-16, 4p |
| Abstrakt: |
The effect of DSP [N-(2-chloroethyl)-N-ethyl-2 bromobenzylamine], a neurotoxin which selectively lesions noradrenergic projections from the locus coeruleus, on thyrotropin (TSH) secretion was investigated in the rat. DSP treatment (60 mg/kg injected i.p. 10 days prior to experimentation) significantly decreased the noradrenaline (NA) content of the hippocampus, frontal cortex and hypothalamus of the rat brain. DSP treatment did not affect the clonidine (250 μg/kg, i.p.) or TSH-releasing-hormone (TRH 5 μg/kg i.v.) induced stimulation or the isoproterenol induced inhibition of TSH secretion in the rat. These results suggest that the noradrenergic projection from the locus coeruleus to the hypothalamus does not play a significant role in the regulation of TSH secretion. Furthermore, the noradrenergic deficiency did not give rise to the development of the abnormal TSH response to TRH administration which is frequently observed in depression. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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