A spirohydantoin derivative of dimethoxytetrahydronaphthalene: An experimental anticonvulsant.

Autor: Alexander, George, Sinha, Biswajit, Chatterjie, Nithiananda
Zdroj: Neurochemical Research; Apr1984, Vol. 9 Issue 4, p529-533, 5p
Abstrakt: A 2-spirohydantoin of 6,7-dimethoxytetrahydronaphthalene was synthesized and purified. The compound, showing structural similarities to both phenytoin and dopamine, was found to decrease spontaneous motor activity of mice and to exert a pronounced protective effect against convulsive seizures induced by pentylenetetrazol (Metrazol). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index