| Autor: |
Kaiser, Reinhard, Dörries, Rüdiger, Ruf, Bernhard, Pohle, Hans, Martin, Roland, Meulen, Volker |
| Zdroj: |
Journal of Neurology; 1991, Vol. 238 Issue 6, p331-336, 6p |
| Abstrakt: |
Cerebrospinal fluid (CSF) and serum samples from 16 HIV-seropositive subjects were examined by ELISA and isoelectric focusing for the presence of HIV-specific immunoglobulin G (IgG) subclass antibodies. Autochthonous synthesis of IgG in the CSF was demonstrated in 11 patients. Intrathecally synthesized antibodies specific for individual HIV structural proteins were largely restricted to IgG (10 of 11 patients). One patient revealed additional local synthesis of IgG antibodies related to HIV-p15. In another patient locally produced antibodies specific for HIV consisted entirely of IgG. In this patient amounts of locally produced antibodies were too low to be detected by routine procedures (calculation from an evaluation graph). No local synthesis of HIV-related IgG was demonstrated in any patient. Further studies will be needed to show whether determination of IgG-subclass-restricted antibodies to HIV is of prognostic value. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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