| Autor: |
Takamatsu, Junta, Sugawara, Masahiro, Kuma, Kanji, Kobayashi, Akira, Matsuzuka, Fumio, Mozai, Toshiji, Hershman, Jerome M., Takamatsu, J, Sugawara, M, Kuma, K, Kobayashi, A, Matsuzuka, F, Mozai, T, Hershman, J M |
| Předmět: |
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| Zdroj: |
Annals of Internal Medicine; Mar84, Vol. 100 Issue 3, p372-375, 4p, 1 Chart, 1 Graph |
| Abstrakt: |
Triiodothyronine (T3)-predominant Graves' disease is characterized by persistently high serum T3 level, normal serum thyroxine (T4) level, and high (greater than 20) serum T3/T4 ratio (nanograms/micrograms) during thionamide drug therapy. We studied the clinical course of 30 patients with T3-predominant Graves' disease. After receiving drug therapy for 1 to 4 years, 27 patients with T3-predominant Graves' disease had relapses, whereas only 9 control patients with Graves' disease whose serum T3/T4 ratio had become persistently normal (less than 20) had relapses. The T3-predominant patients had greater serum TSH receptor antibody activity, thyroid T4 5'-deiodinase activity, and decreased T3 content of thyroglobulin when compared with the control patients. Our findings show that patients with T3-predominant Graves' disease are unlikely to have a long-term remission with drug therapy. The cause of high serum T3/T4 ratio is due, in part, to the more active thyroid T4 5'-deiodinase that may be mediated by high levels of Graves' immunoglobulin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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