Reduced HIV transmission at subsequent pregnancy in a resource-poor setting.
| Autor: | Felicity Zvanyadza Gumbo, Kandawasvika, Gwendoline Quintoline, Duri, Kerina, Mapingure, Munyaradzi Paul, Kurewa, Nyaradzai Edith, Nathoo, Kusum, Rusakaniko, Simbarashe, Chirenje, Mike Zvavahera, Stray-Pedersen, Babill, Gumbo, Felicity Zvanyadza |
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| Předmět: |
COHORT analysis
HIV infection transmission PREGNANT women PREGNANCY complications HIV infections HIV prevention NEVIRAPINE ANTI-HIV agents RESEARCH COMMUNICABLE diseases EVALUATION of human services programs REVERSE transcriptase inhibitors CROSS-sectional method RESEARCH methodology MEDICAL cooperation EVALUATION research TREATMENT effectiveness COMPARATIVE studies POVERTY VERTICAL transmission (Communicable diseases) HIV |
| Zdroj: | Tropical Doctor; Jul2011, Vol. 41 Issue 3, p132-135, 4p |
| Abstrakt: | Several studies indicate that HIV-infected women continue to have children. We set out to determine the trend in HIV transmission at subsequent pregnancies. From 2002-2003, pregnant women were enrolled in a single dose nevirapine-based Prevention of Mother-to-Child Transmission of HIV (PMTCT) programme. Six years later, women with subsequent children in this cohort were identified and their children's HIV status determined. From 330 identified HIV-infected mothers, 73 had second/subsequent children with HIV results. Of these, nine (12.3%, 95% confidence interval [CI]: 4.6-20.1%) children were HIV-infected. Of the 73 second children, 51 had older siblings who had been initially enrolled in the study with definitive HIV results with an infection rate of 17/51 (33.3%, 95% CI: 19.9-46.7). About 35% of the women had been on antiretroviral drugs. These results demonstrate lower subsequent HIV transmission rates in women on a national PMTCT programme in a resource-poor setting with the advent of antiretroviral therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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