Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.

Autor: Schreiber-Agus, Nicole, Meng, Yong, Hoang, Tin, Hou, Jr., Harry, Chen, Ken, Greenberg, Roger, Cordon-Cardo, Carlos, Lee, Han-Woong, DePinho, Ronald A.
Předmět:
Zdroj: Nature; 6/4/1998, Vol. 393 Issue 6684, p483, 5p, 16 Color Photographs, 3 Black and White Photographs, 2 Diagrams, 6 Graphs
Abstrakt: Presents research which showed that mice lacking the Mxi1 protein exhibit progressive, multisystem abnormalities. Mxi1 an antagonist of Myc oncoproteins; Possibility that Mxi1 is a tumor-suppressor gene; Chromosomal location of gene; Traits of mice; Proliferative ability of Mxi1-deficient cell types; Role of Mxi1.
Databáze: Complementary Index