Pulsatile spinal cord surrogate for intradural neuromodulation studies.

Autor: Wilson, S., Howard, M. A., Rossen, J. D., Brennan, T. J., Dalm, B. D., Dahdaleh, N. S., Utz, M., Gillies, G. T.
Předmět:
Zdroj: Journal of Medical Engineering & Technology; Jan2012, Vol. 36 Issue 1, p22-25, 4p
Abstrakt: We have designed, built and tested a novel spinal cord surrogate that mimics the low-amplitude cardiac-driven pulsations of the human spinal cord, for use in developing intradural implants to be used in a novel form of neuromodulation for the treatment of intractable pain and motor system dysfunction. The silicone surrogate has an oval cross section, 10 mm major axis × 6 mm minor axis, and incorporates a 3 mm diameter × 3 cm long angioplasty balloon that serves as the pulsation actuator. When pneumatically driven at 1 Hz and 1.5 atmospheres (≈≈ 1140 mm Hg), the surrogate's diametric pulsation is ≈≈ 100 μm, which corresponds well to in vivo observations. The applications for this surrogate are presented and discussed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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