Acute nickel intoxication by dialysis.

Autor: Webster, James D., Parker, Thomas F., Alfrey, Al C., Smythe, W. R., Kubo, Hideo, Neal, George, Hull, Alan R., Webster, J D, Parker, T F, Alfrey, A C, Kubo, H, Neal, G, Hull, A R
Předmět:
Zdroj: Annals of Internal Medicine; May80, Vol. 92 Issue 5, p631-633, 3p, 1 Chart, 1 Graph
Abstrakt: Nickel intoxication was observed in a group of 23 dialyzed patients when leaching of nickel-plated stainless steel water heater tank contaminated the dialysate. Symptoms occurred during and after dialysis at plasma nickel concentrations of approximately 3 mg/L. Symptoms included nausea (37 of 37), vomiting (31 of 37), weakness (29 of 37), headache (22 of 37), and palpitation (two of 37). Remission of symptoms occurred spontaneously, generally 3 to 13 hours after cessation of dialysis. The evidence indicated that the nickel became bound in the plasma after crossing the membrane, resulting in a higher concentration in the plasma than in the dialysate and preventing its removal by dialysis. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index