FDG-PET/CT Compared with Conventional Imaging in the Detection of Distant Metastases of Primary Breast Cancer.

Autor:	NIIKURA, NAOKI, COSTELLOE, COLLEEN M., MADEWELL, JOHN E., HAYASHI, NAOKI, YU, TSE-KUAN, LIU, JUN, PALLA, SHANA L., TOKUDA, YUTAKA, THERIAULT, RICHARD L., HORTOBAGYI, GABRIEL N., UENO, NAOTO T.
Předmět:	BREAST tumors CHEST X rays COMPARATIVE studies DEOXY sugars FISHER exact test EVALUATION of medical care METASTASIS RADIOGRAPHY RADIONUCLIDE imaging RADIOPHARMACEUTICALS RESEARCH funding TOMOGRAPHY POSITRON emission tomography TUMOR classification ULTRASONIC imaging DATA analysis RETROSPECTIVE studies DATA analysis software
Zdroj:	Oncologist; Aug2011, Vol. 16 Issue 8, p1111-1119, 9p, 1 Diagram, 5 Charts
Abstrakt:	Purpose. Evidence from studies with small numbers of patients indicates that 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) accurately detects distant metastases in the staging of primary breast cancer. We compared the sensitivity and specificity of PET/CT and conventional imaging (CT, ultrasonography, radiography, and skeletal scintigraphy) for the detection of distant metastases in patients with primary breast cancer. Patients and Methods. We performed a retrospective review that identified 225 patients with primary breast cancer seen from January 2000 to September 2009 for whom PET/CT data were available for review. Imaging findings were compared with findings on biopsy, subsequent imaging, or clinical follow-up. Sensitivity and specificity in the detection of distant metastases were calculated for PET/CT and conventional imaging. Fisher's exact tests were used to test the differences in sensitivity and specificity between PET/CT and conventional imaging. Results. The mean patient age at diagnosis was 53.4 years (range, 23-84 years). The sensitivity and specificity in the detection of distant metastases were 97.4% and 91.2%, respectively, for PET/CT and 85.9% and 67.3%, respectively, for conventional imaging. The sensitivity and specificity of PET/CT were significantly higher than those of conventional imaging (p = .009 and p < .001, respectively). Eleven cases of distant metastases detected by PET/CT were clinically occult and not evident on conventional imaging. Conclusion. PET/CT has higher sensitivity and specificity than conventional imaging in the detection of distant metastases of breast cancer. A prospective study is needed to determine whether PET/CT could replace conventional imaging to detect distant metastases in patients with primary breast cancer. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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