| Autor: |
Sattler, Fred R., Ko, Richard, Antoniskis, Diana, Shields, Mark, Cohen, Jordan, Nicoloff, John, Leedom, John, Koda, Robert, Sattler, F R, Ko, R, Antoniskis, D, Shields, M, Cohen, J, Nicoloff, J, Leedom, J, Koda, R |
| Předmět: |
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| Zdroj: |
Annals of Internal Medicine; 6/1/91, Vol. 114 Issue 11, p937-940, 4p, 2 Charts, 2 Graphs |
| Abstrakt: |
Objective: To determine whether concurrent treatment with acetaminophen and zidovudine impairs clearance of zidovudine, thereby increasing the risk for zidovudine-induced hematologic toxicity.Design: Dose escalation, drug interaction study.Setting: University clinical research center.Patients: Patients with the acquired immunodeficiency syndrome (AIDS) or advanced AIDS-related complex.Interventions: Acetaminophen and 200 mg of zidovudine simultaneously every 4 hours. For 13 patients, the unit dosage of acetaminophen was 325 mg for 3 days; for 8 patients, the dosage was 650 mg for 3 days; and, for 6 patients, the dosage was 650 mg for 7 days.Measurements: Zidovudine clearance and production of the glucuronide conjugate of zidovudine were assessed after acetaminophen treatment.Main Results: Neither zidovudine clearance nor production of the glucuronide conjugate of zidovudine was impaired after treatment with acetaminophen. Clearance of zidovudine was actually accelerated by 5%, 11%, and 33% with the three acetaminophen regimens, respectively (P = 0.002 by analysis of variance; P = 0.04 for linear trend when changes in the area-under-the-curve for zidovudine were compared).Conclusion: Because serum concentrations of zidovudine decrease after the coadministration of acetaminophen, a pharmacokinetic interaction between zidovudine and acetaminophen is unlikely to increase the risk for hematologic toxicity associated with zidovudine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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