| Autor: |
Read, Alexandra E., Donegan, Elizabeth, Lake, John, Ferrell, Linda, Galbraith, Cynthia, Kuramoto, I.K., Zeldis, Jerome B., Ascher, Nancy L., Roberts, John, Wright, Teresa L., Read, A E, Donegan, E, Lake, J, Ferrell, L, Galbraith, C, Zeldis, J B, Ascher, N L, Roberts, J, Wright, T L |
| Předmět: |
|
| Zdroj: |
Annals of Internal Medicine; 2/15/91, Vol. 114 Issue 4, p282-284, 3p, 1 Graph |
| Abstrakt: |
Objective: To determine the prevalence of antibodies to hepatitis C virus (anti-HCV) among patients undergoing liver transplantation and the relation between anti-HCV and post-transplant hepatitis.Design: Retrospective cohort.Patients: Serum samples from 128 patients who underwent liver transplantation. Sixty-six patients who had 6 months of follow-up and for whom both pretransplant and post-transplant serum samples were available were included in a study to asses the relation between anti-HCV and post-transplant hepatitis.Measurements: Sera were tested for anti-HCV using an enzyme-linked immunosorbent assay (ELISA) and, if positive, two confirmatory tests were done. Patients had a biopsy every week until two specimens showed no abnormal findings.Main Results: Only patients with chronic non-A, non-B hepatitis (15 of 30; 50%), alcoholic cirrhosis (7 of 19; 37%), and chronic hepatitis B infection (3 of 11; 27%) were anti-HCV positive. No patient with another form of chronic liver disease or with acute liver failure due to non-A, non-B hepatitis was anti-HCV positive. After transplantation, loss of anti-HCV was frequent and acquisition rare. Hepatitis developed in the graft in 17% of patients, but the incidence was similar among anti-HCV negative and anti-HCV-positive patients.Conclusions: Hepatitis C virus is a common cause of chronic liver disease in patients requiring liver transplantation, but anti-HCV is rarely found in patients with acute liver failure. Previous HCV infection, based on detection of anti-HCV, is not an independent risk factor for post-transplant hepatitis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
