| Autor: |
Groopman, Jerome E., Mayer, Kenneth H., Sarngadharan, M. G., Ayotte, David, Devico, Anthony L., Finberg, Robert, Sliski, Ann H., Allan, J. Davis, Gallo, Robert C., Groopman, J E, Mayer, K H, Ayotte, D, Devico, A L, Finberg, R, Sliski, A H, Allan, J D, Gallo, R C |
| Předmět: |
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| Zdroj: |
Annals of Internal Medicine; Mar85, Vol. 102 Issue 3, p334-337, 4p, 2 Charts |
| Abstrakt: |
We studied a cohort of 45 homosexual men with the acquired immunodeficiency syndrome, 78 with persistent unexplained generalized lymphadenopathy, and 160 asymptomatic homosexual controls for serologic evidence of infection with human T-lymphotropic virus type III (HTLV-III). Study participants were recruited from a community-based health center and a university hospital practice. Ninety-eight percent of men with the syndrome and greater than 90% of men with generalized lymphadenopathy had antibody to HTLV-III, while 21% of the controls were positive (p less than 0.001). Six patients with generalized lymphadenopathy developed the acquired immunodeficiency syndrome over 2 years; all were seropositive for HTLV-III. Thirty-six asymptomatic controls had had sexual contact with a man with the syndrome; receptive anal intercourse in this group was associated with seropositivity for HTLV-III. These data suggest that persistent generalized lymphadenopathy and the acquired immunodeficiency syndrome are part of a clinical spectrum of HTLV-III infection and that most high-risk homosexual men in some regions of the United States have not yet been infected with this virus. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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