| Autor: |
Gonotkov, M., Golovko, V. |
| Předmět: |
|
| Zdroj: |
Bulletin of Experimental Biology & Medicine; Decv2011, Vol. 152 Issue 2, p169-172, 4p |
| Abstrakt: |
Experiments on spontaneously contracting strips from sinoatrial region of the hearts of 2-month-old albino mice showed that cesium (Cs), a blocker of hyperpolarization-activated I current, in a concentration of 1 mM produced the greatest negative chronotropic effect on the duration of diastolic depolarization phase (75%), its rate (59%), and action potential duration (29%). The threshold concentration of Cs was approximately 0.15 mM. In a concentration of about 8.5 mM, spontaneous generation of action potentials stopped. The effect was reversible. Thus, blockade of I current by Cs reduced the rate of action potential generation in cells of mouse sinoatrial node by ~42% in comparison with controls. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink