Influence of combined therapy with mevinolin and interruption of bile-acid reabsorption on low density lipoproteins in heterozygous familial hypercholesterolemia.
| Autor: | Grundy, Scott M., Vega, Gloria Lena, Bilheimer, David W., Grundy, S M, Vega, G L, Bilheimer, D W |
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| Předmět: |
DRUG therapy
LOW density lipoproteins HYPERCHOLESTEREMIA HYDROCARBONS ILEUM surgery ANTILIPEMIC agents APOLIPOPROTEINS COMBINATION drug therapy CHOLESTEROL COMBINED modality therapy COMPARATIVE studies DYNAMICS RESEARCH methodology MEDICAL cooperation METABOLISM RESEARCH EVALUATION research GENETIC carriers LOVASTATIN FAMILIAL hypercholesterolemia THERAPEUTICS |
| Zdroj: | Annals of Internal Medicine; Sep85, Vol. 103 Issue 3, p339-343, 5p |
| Abstrakt: | Patients with heterozygous familial hypercholesterolemia have a 50% deficiency of receptors for plasma low density lipoproteins (LDL) that induces a marked increase in plasma LDL levels. Two therapeutic measures that seem to increase the synthesis of LDL receptors are interruption of the enterohepatic circulation of bile acids with either bile-acid sequestrants or the ileal-exclusion operation, and competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase with mevinolin or compactin. To determine the effectiveness of this combination and the mechanisms of lowering LDL levels, we measured turnover rates of LDL apoprotein (apo-LDL) before and during treatment with mevinolin and colestipol in eight patients with heterozygous familial hypercholesterolemia. Drug therapy reduced LDL cholesterol levels by an average of 52%; this response was due to a 40% increase in fractional catabolic rate of apo-LDL and a 26% decrease in its production rate. A similar response was obtained in two patients who had previously had an ileal-exclusion operation for severe hypercholesterolemia and who were treated with mevinolin. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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