| Autor: |
Rahmat, Javed, Gelfand, Richard L., Selfand, Michael C., Winchester, James F., Schreiner, George E., Zimmerman, Hyman J., Rahmat, J, Gelfand, R L, Gelfand, M C, Winchester, J F, Schreiner, G E, Zimmerman, H J |
| Předmět: |
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| Zdroj: |
Annals of Internal Medicine; Jan85, Vol. 102 Issue 1, p56-58, 3p |
| Abstrakt: |
Captopril, the competitive inhibitor of angiotensin-converting enzyme, is of considerable benefit in difficult-to-manage forms of hypertension. Its use has been associated with various untoward effects, but hepatic injury has not been widely reported. We treated a patient with captopril-associated cholestatic jaundice; a review of cases reported to the drug manufacturer and a review of the literature showed 13 additional cases of hepatic injury associated with captopril. In 9 of these the jaundice was categorized as cholestatic, and in 4 of the remaining 5 as mixed cholestatic-hepatocellular. These findings show that jaundice may be an idiosyncratic side effect of captopril, and that captopril-associated jaundice characteristically has strongly cholestatic features. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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