| Autor: |
Martin, Paul J., Shulman, Howard M., Schubach, William H., Hansen, John A., Fefer, Alexander, Miller, George, Thomas, E. Donnali, Martin, P J, Shulman, H M, Schubach, W H, Hansen, J A, Fefer, A, Miller, G, Thomas, E D |
| Předmět: |
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| Zdroj: |
Annals of Internal Medicine; Sep84, Vol. 101 Issue 3, p310-315, 6p, 2 Charts, 2 Graphs |
| Abstrakt: |
Two patients with acute leukemia were treated with chemoradiotherapy and allogeneic bone marrow transplantation. Despite the prophylactic use of methotrexate after grafting, both patients developed severe graft-versus-host disease that was refractory to treatment with methylprednisolone. The graft-versus-host disease was then treated with a monoclonal antibody, 64.1, that reacts with a p19 antigen on human T cells. The disease responded dramatically to this treatment, but both patients subsequently developed a fatal polyclonal lymphoproliferative disorder arising in donor-derived B cells. Hybridization studies showed Epstein-Barr virus in both tumors. The combined effect of severe end-stage graft-versus-host disease and potent immunosuppressive therapy probably resulted in a progressive immunodeficiency syndrome that abrogated the T-cell-mediated surveillance mechanism that normally modulates the proliferation of Epstein-Barr-virus-infected B lymphocytes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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