Colony-stimulating factors and host defense.
| Autor: | Weisbart, Richard H., Gasson, Judith C., Golde, David W., Weisbart, R H, Gasson, J C, Golde, D W |
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| Předmět: |
COLONY-stimulating factors (Physiology)
AIDS treatment NEUTROPHILS GRANULOCYTE-macrophage colony-stimulating factor AIDS BONE marrow CELL receptors CELLULAR immunity CLINICAL trials COMPARATIVE studies GROWTH factors HEMATOPOIESIS LUNG tumors RESEARCH methodology MEDICAL cooperation NEUTROPENIA RESEARCH STEM cells EVALUATION research SMALL cell carcinoma THERAPEUTICS |
| Zdroj: | Annals of Internal Medicine; 2/15/89, Vol. 110 Issue 4, p297-303, 7p |
| Abstrakt: | Colony-stimulating factors are growth factors responsible for the proliferation and the maturation of bone marrow stem cells to fully differentiated granulocytes and monocytes. In addition to their effects on hematopoiesis, some colony-stimulating factors prime mature cells for enhanced chemotaxis, phagocytosis, and killing in response to physiologic stimuli. The action of colony-stimulating factors is mediated by growth factor receptors on precursor and mature effector cells. The results of studies of granulocyte-macrophage colony-stimulating factors in patients with the acquired immunodeficiency syndrome (AIDS) suggest a possible therapeutic role for colony-stimulating factors in augmenting mechanism of host defense. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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