| Autor: |
Dobmeyer, Thomas S., Dobmeyer, Rita, Wesch, Daniela, Helm, Eilke B., Hoelzer, Dieter, Kabelitz, Dieter |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; Jul2002, Vol. 118 Issue 1, p282-288, 7p |
| Abstrakt: |
Summary. While T cells that express Vγ9 as a variable T-cell receptor chain dominate among peripheral blood γδ T cells in healthy adults, Vδ1 cells are the major subpopulation of γδ T cells in human immunodeficiency virus (HIV)-infected patients. We used intracellular cytokine staining and flow cytometry to analyse whether an imbalance of T helper 1 (Th1)/T helper 2 (Th2) cytokine patterns, as observed in αβ T cells, also occurs in γδ T cells. When compared with healthy HIV-negative subjects, HIV+ patients had a decreased number of interferon-γ (IFN-γ)+ γδ T cells, which showed a linear relation to the CD4+ cell count but not to the plasma viral load. Similar results were obtained when Vγ9 cells were analysed. In contrast, in the Vδ1 subpopulation, the number of IFN-γ+ cells was increased in HIV+ donors when compared with healthy subjects. Even though less impressive, the number of interleukin 4 (IL-4)- and IL-10-producing cells was uniformly inversely correlated with the number of tumour necrosis factor-α+ and IFN-γ+ cells. The increased IFN-γ-producing capacity of Vδ1 cells might represent a compensatory mechanism for the progressive loss of Vγ9 γδ T cells during the course of HIV infection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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