Amoxicillin and ampicillin are not transferred to gastric juice irrespective of Helicobacter pylori status or acid blockade by omeprazole.

Autor: Ortiz, R. A. M., Calafatti, S. A., Corazzi, A., Souza, J. M., Deguer, M., De Souza, C. A. F., Marchioretto, M. A. M., Bernasconi, G., Ferraz, J. G. P., Pedrazzoli, J.
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Zdroj: Alimentary Pharmacology & Therapeutics; Jun2002, Vol. 16 Issue 6, p1163-1170, 8p
Abstrakt: Background: The effects of proton pump inhibitors and Helicobacter pylori infection on the distribution of drugs used for the eradication of the bacteria are poorly understood. Aim: The aim of this study was to investigate the effects of a 7-day administration of 20 mg of omeprazole on the pharmacokinetics of amoxicillin and ampicillin in the plasma, saliva and gastric juice of individuals with and without H. pylori infection. Methods: Fifty-four healthy volunteers without endoscopic lesions were enrolled. Twenty-six volunteers were included in the amoxicillin study and 28 individuals in the ampicillin study. Each study had an open randomized two-period crossover design and a 21-day washout period between phases. Plasma, saliva and gastric juice concentrations of amoxicillin and ampicillin in subjects with and without omeprazole pre-treatment were measured by reversed-phase HPLC using UV detection. Results: Neither pre-treatment with omeprazole nor H. pylori infection interfered with the plasma bioavailability of amoxicillin or ampicillin, as assessed by the AUC0–2 h . Neither ampicillin nor amoxicillin were detected in saliva or gastric juice in any study phase. Conclusion: Short-term treatment with omeprazole does not interfere with the pharmacokinetics of amoxicillin or ampicillin. Our results also exclude the presence of a transfer mechanism for amoxicillin or ampicillin from the plasma to the gastric lumen. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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