| Autor: |
Meneghelli, U. G, Boaventura, S, Moraes-Filho, J. P. P, Leitão, O, Ferrari, A. P, Almeida, J. R, Magalhães, A. F. N, Castro, L. P, Haddad, M. T, Tolentino, M, Jorge, J. L, Silva, E, Maguilnik, I, Fischer, R |
| Předmět: |
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| Zdroj: |
Diseases of the Esophagus; Mar2002, Vol. 15 Issue 1, p50-56, 7p |
| Abstrakt: |
SUMMARY. Patients with reflux esophagitis (grade II or III, Savary–Miller, intention-to-treat, n =256, age range 19–82 years) were randomly assigned to a double-blind, double-dummy treatment with either pantoprazole 40 mg once daily or ranitidine 150 mg twice daily. After 4 weeks, each patient was clinically and endoscopically assessed. Failure to heal required a further 4 weeks of treatment and a new evaluation thereafter. After 4 weeks, healing of lesions was confirmed in 63% (69 out of 109) of patients receiving pantoprazole and in 22% (25 out of 113) receiving ranitidine (P < 0.001, per protocol population). After 8 weeks, the cumulative healing rates were 88% and 46%, respectively (P < 0.001). Complete freedom from esophagitis-related symptoms (acid eructation, heartburn, pain while swallowing) was greater in the pantoprazole than in ranitidine group after 2 and 4 weeks (74% vs. 47%; 87% vs. 52%, respectively, P < 0.001). After 4 weeks, the healing rate was 76% in Helicobacter pylori (Hp )-positive vs. 45% in Hp -negative patients treated with pantoprazole (P < 0.01). The Hp status did not influence healing rates in patients treated with ranitidine. The most frequent adverse events in the pantoprazole group were diarrhea and somnolence (2–3% of patients), and in the ranitidine group, headache, diarrhea, dizziness, increase of liver enzymes and pruritus (2–4% of patients). In conclusion, pantoprazole was more effective than ranitidine in the healing rate and relief from reflux esophagitis-associated symptoms, and Hp infection was associated with higher healing rate during therapy with pantoprazole but not with ranitidine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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