| Autor: |
Yun-Zhou Jin, Da-Xu Fu, Nan Ma, Zhan-Cheng Li, Quan-Hai Liu, Lin Xiao, Rong-Hua Zhang |
| Předmět: |
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| Zdroj: |
Molecules; Nov2011, Vol. 16 Issue 11, p9368-9385, 18p, 4 Diagrams, 2 Charts, 1 Graph |
| Abstrakt: |
Eighteen novel 3-substituted-indolin-2-ones containing chloropyrroles were synthesized and their biological activities were evaluated. The presence of a chlorine atom on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethylamino) ethylcarbamoyl group as a substituent at the C-4′ position of the pyrrole enhanced the antitumor activities notably. IC50 values as low as 0.32, 0.67, 1.19 and 1.22 μM were achieved against non-small cell lung cancer (A549), oral epithelial (KB), melanoma (K111) and large cell lung cancer cell lines (NCI-H460), respectively. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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