| Autor: |
Cherneva, Zheyna Vlaeva, Denchev, Stefan Veselinov, Gospodinova, Mariana Vasileva, Milcheva, Nora Petrova, Petrova, Mariana Genova, Cherneva, Radostina Vlaeva |
| Předmět: |
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| Zdroj: |
Acute Cardiac Care; Dec2011, Vol. 13 Issue 4, p211-218, 8p, 8 Charts |
| Abstrakt: |
Background: The clinical significance of moment measurements (admission and fasting glycaemia), persistent (hyperglycaemic index, HGI; time average glucose, TAG; mean glucose; maximum glucose) or chronic hyperglycaemia (HbA1c, estimated average glucose, eAG) is still elusive in clinical practice. Aim: To identify the clinical significance of hyperglycaemia in ACS. Methods: The study included 226 consecutive patients with ACS. Indicators for hyperglycaemia were defined, calculated and a correlation analysis with standard parameters-EF, maximum CPK, maximum CPK-MB and troponin was performed. Patients were followed up for 12 months. Results: Indicators for persistent and chronic hyperglycaemia correlated neither to ejection fraction, nor to the enzymes for myocardial necrosis ( P > 0.05). In contrast, acute hyperglycaemia correlated negatively with ventricular systolic dysfunction ( P == 0.001/0.007) and positively with maximum CPK, MB and troponin ( P == 0.0001/0.008). TAG was an independent predictor for 6-month re-hospitalization ( P == 0.027) because of cardiac complications. Conclusion: Glycaemia at admission and fasting glucose could be used as metabolic surrogate markers for ventricular systolic dysfunction and TAG as an independent surrogate marker for six-month re-hospitalization. None of the indicators for hyperglycaemia could be used as independent prognostic factors for survival. Hyperglycaemia rather reflects an underlying impairment in glucose metabolism. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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