Low Estimated Glomerular Filtration Rate Is a Major Determinant of Low Ankle-Brachial Index and Toe-Brachial Index in Type 2 Diabetes.
| Autor: | Sheen, Yi-Jing, Lin, Jainn-Liang, Lee, I-Te, Hsu, Yuan-Nian, Li, Tsai-Chung, Sheu, Wayne Huey-Herng |
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| Předmět: |
ATHEROSCLEROSIS risk factors
PERIPHERAL vascular disease diagnosis AGE distribution ANALYSIS of covariance ANALYSIS of variance BIOMARKERS CARDIOVASCULAR diseases risk factors CHI-squared test CONFIDENCE intervals STATISTICAL correlation PEOPLE with diabetes EPIDEMIOLOGY EXERCISE GLOMERULAR filtration rate TYPE 2 diabetes PERIPHERAL vascular diseases REGRESSION analysis KIDNEY failure RESEARCH funding SEX distribution STATISTICS T-test (Statistics) TOES DATA analysis MULTIPLE regression analysis CROSS-sectional method RETROSPECTIVE studies ANKLE brachial index DATA analysis software DESCRIPTIVE statistics |
| Zdroj: | Angiology; Feb2012, Vol. 63 Issue 1, p55-61, 7p |
| Abstrakt: | We enrolled 1461 Taiwanese type 2 diabetic outpatients with ankle-brachial index (ABI) and toe-brachial index (TBI) examinations, excluding participants with history of stroke, end-stage renal disease, malignancy, acute myocardial infarction, amputation, and overt calcification of the lower limbs (ABI >1.3). Ankle-brachial index values <0.9 were found in 2.8% of the patients and 5.7% had TBI <0.6. Estimated glomerular filtration rate (eGFR; 90 ± 33 mL/min per 1.73 m2) obtained from 473 patients correlated significantly with both ABI and TBI. Progressive eGFR decline was observed in 419 participants with normal ABI and TBI, 35 with normal ABI but low TBI, and 19 with low ABI and normal or low TBI (P for trend <.001). After adjusting for confounding factors, age and eGFR were significantly associated with TBI and ABI. Low eGFR is associated with peripheral arterial disease in type 2 diabetes with mild to moderate renal insufficiency. [ABSTRACT FROM PUBLISHER] |
| Databáze: | Complementary Index |
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