Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadaiKadotaElectronic supplementary information (ESI) available: Experimental procedures, crystallographic information, spectral data for all new compounds, and results of cell growth analysis. CCDC 842822. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c1cc15557a

Autor: Ohno, Osamu, Chiba, Tatsuhiko, Todoroki, Seiji, Yoshimura, Hideaki, Maru, Norihito, Maekawa, Ken, Imagawa, Hiroshi, Yamada, Kaoru, Wakamiya, Atsushi, Suenaga, Kiyotake, Uemura, Daisuke
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Zdroj: Chemical Communications; Nov2011, Vol. 47 Issue 46, p12453-12455, 3p
Abstrakt: Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadaiKadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2induced apoptosis in HL60 human leukemia cells. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index