Mapping the receptor site for α-scorpion toxins on a Na+ channel voltage sensor.
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| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America; 9/13/2011, Vol. 108 Issue 37, p15426-15431, 6p |
| Abstrakt: | The article presents a study on the mapping of α-scorpion toxins receptor site on a sodium channel voltage sensor. It notes that the findings reveal that α -scorpion toxins inhibit fast inactivation by interacting with a receptor site formed by domains I and IV and bind with the sodium channels. The binding of Leiurus quinquestriatus hebraeus toxin II (LqhII) to the voltage sensor in its resting state takes place as a result of the analysis with the Rosetta-Membrane algorithm. |
| Databáze: | Complementary Index |
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