| Autor: |
BESWICK, D. T., CULLEN, R. E., RYLANCE, G. W. |
| Zdroj: |
Archives of Disease in Childhood; Aug1984, Vol. 59 Issue 8, p758-761, 4p, 1 Chart, 3 Graphs |
| Abstrakt: |
Two methods of predicting the optimal dose of theophylline in children aged 2 to 13 years were assessed. The observed plasma concentration was within 95% confidence limits of that predicted on eight of 14 occasions using a traditional multiple point pharmacokinetic method. Using a nomogram derived from the plasma concentration 6 hours after dosing and the logarithm of the calculated dose, which were significantly correlated, there was a significant relation between the dose predicted and the actual dose required to produce a concentration of 55 mumol/l. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
