Quantification of enterochromaffin cells with serotonin immunoreactivity in the duodenal mucosa in coeliac disease.

Autor: WHEELER, E. E., CHALLACOMBE, D. N.
Zdroj: Archives of Disease in Childhood; Jun1984, Vol. 59 Issue 6, p523-527, 5p, 2 Black and White Photographs, 2 Graphs
Abstrakt: Enterochromaffin cells in the duodenal mucosa were stained by using a monoclonal antibody against serotonin immunoreactive sites and an indirect immunoperoxidase technique. A semi-automatic image analysing system showed increased numbers of these cells in patients with untreated coeliac disease compared with a control group. The number of serotonin positive granules in individual enterochromaffin cells also seemed to be increased in patients with coeliac disease, a finding which may be related to the pathogenesis of this disorder. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index