| Autor: |
Ichikawa, Kiyoshi, Yamato, Tokuhisa, Ojima, Kazuma, Tsuji, Atsutoshi, Ishikawa, Kohtaro, Kusama, Hiroshi, Kojima, Masami |
| Předmět: |
|
| Zdroj: |
Clinical & Experimental Pharmacology & Physiology; May/Jun2002, Vol. 29 Issue 5/6, p423-427, 5p |
| Abstrakt: |
SUMMARY 1. The effects of KAD-1229 (a novel non-sulphonylurea agent), voglibose (an α -glucosidase inhibitor) and nateglinide (a non-sulphonylurea antihyperglycaemic agent) on hyperglycaemia induced by a meal load were assessed in diabetic rats. 2. KAD-1229 suppressed the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose ) up to 5 h after the meal load. 3. Voglibose also suppressed the increase in plasma glucose levels; however, a significant decrease in AUCglucose following voglibose was not observed. 4. Nateglinide suppressed the increase in plasma glucose levels at 30 min and 1 h after the meal load; however, plasma glucose levels was above control thereafter and the AUCglucose was not decreased. 5. The results indicate that KAD-1229 has an antihyperglycaemic effect and KAD-1229 is suggested to be a suitable agent for controlling post-prandial hyperglycaemia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
