| Autor: |
Chen, Xiao-ping, Qian, Lin-lin, Jiang, Hong, Chen, Jiang-hua |
| Předmět: |
|
| Zdroj: |
International Journal of Clinical Oncology; Oct2011, Vol. 16 Issue 5, p519-523, 5p |
| Abstrakt: |
Background: Ginsenoside Rg3 is an extract from the natural product ginseng. Previous studies have linked Rg3 with anti-metastasis of cancer in vivo and in vitro. CXC receptor 4 (CXCR4) is a vital molecule in migration and homing of cancer to the docking regions. Methods: In this study, the effects of Rg3 on CXCR4 expression were investigated in a breast cancer cell line. Immunohistochemistry, chemotaxis and wound healing mobility assays were performed in cultured MDA-MB-231 cells. Results: At a dosage without obvious cytotoxicity, Rg3 treatment elicits a weak CXCR4 stain color, decreases the number of migrated cells in CXCL12-elicited chemotaxis and reduces the width of the scar in wound healing. Conclusion: This work suggests that Rg3 is a new CXCR4 inhibitor from a natural product. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink