| Autor: |
Borkar, Vibhor V, Verma, Savita, Bhalla, AK |
| Předmět: |
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| Zdroj: |
Pediatric Diabetes; Aug2010, Vol. 11 Issue 5, p345-350, 6p, 4 Charts, 1 Graph |
| Abstrakt: |
Borkar VV, Devidayal, Verma S, Bhalla AK. Low levels of vitamin D in North Indian children with newly diagnosed type 1 diabetes. Background: To find out whether vitamin D levels are lower in children with newly diagnosed type 1 diabetes (T1D) as compared to non-diabetic subjects. Methods: Plasma levels of vitamin D (25-OHD) were measured by high performance liquid chromatography (HPLC) in 50 children aged between 6 and 12 yr within a week of diagnosis of T1D, and in 50 healthy children. Results: The mean levels of vitamin D were significantly lower in patients as compared to their controls [20.02 ± 10.63 ng/mL (50.05 ± 26.57 mmol/L) vs. 26.16 ± 12.28 ng/mL (65.4 ± 30.7 mmol/L), p-value 0.009]. Twenty-nine (58%) children in the study group were vitamin D deficient (25-OHD level < 20 ng/mL or < 50 mmol/L) as compared to only 16 (32%) in the control group. Overall, 43 (86%) diabetic and 38 (76%) healthy children were either vitamin D deficient or insufficient. Conclusion: These results suggest that vitamin D levels are low at the onset of T1D, and they strongly support the need for further clinical studies to prospectively evaluate the effect of vitamin D supplementation on T1D rates in this patient population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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