| Autor: |
Fall, C. H. D., Goggin, P. M., Hawtin, P., Fine, D., Duggleby, S., Fall, C H |
| Zdroj: |
Archives of Disease in Childhood; Oct1997, Vol. 77 Issue 4, p310-314, 5p, 4 Charts |
| Abstrakt: |
Aim: To examine childhood correlates of Helicobacter pylori infection in adults.Design: Follow up study of men and women whose birth weight, weight at age 1 year, and feeding in infancy were recorded by health visitors. Data on childhood housing conditions were obtained by recall.Subjects: 631 men and 389 women born in Hertfordshire during 1920-30 and still living in the east or northwest districts of the county.Main Outcome Measures: Serum H pylori IgG antibodies measured by enzyme linked immunosorbent assay.Results: Independent of their current social class, subjects were more likely to be H pylori seropositive if they had large numbers of siblings (p < 0.0001), and if they had lived in a crowded house (p = 0.001), or shared a bedroom or bed in childhood (p = 0.02). Low weight at 1 year was associated with increased seropositivity rates in men (p = 0.0002), but not women (p = 0.8). Men and women who were breast fed in infancy were less likely to be seropositive than those who were bottle fed (p = 0.08).Conclusions: The findings support the current view that H pylori infection is often acquired in childhood by close person to person contact, and persists into adult life. H pylori infection may be a cause of failure to thrive in infancy, especially in boys. Alternatively, small infants may be more susceptible to infection. Breast feeding may prevent early infection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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