Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levodopa requirements in fluctuating parkinsonian patients.
Autor: | Baas, H., Beiske, A. G., Ghika, J., Jackson, M., Oertel, W. H., Poewe, W., Ransmayr, G. |
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Předmět: |
DOPA
DRUG therapy for Parkinson's disease ANTIPARKINSONIAN agents BIOAVAILABILITY COMBINATION drug therapy CLINICAL trials COMPARATIVE studies DOSE-effect relationship in pharmacology ENZYME inhibitors KETONES RESEARCH methodology MEDICAL cooperation PHENOLS RESEARCH EVALUATION research RANDOMIZED controlled trials BLIND experiment SEVERITY of illness index PHARMACODYNAMICS THERAPEUTICS |
Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry; Oct1997, Vol. 63 Issue 4, p421-428, 8p |
Abstrakt: | |
Databáze: | Complementary Index |
Externí odkaz: |