| Autor: |
Szabados, Florian, Marlinghaus, Lennart, Korte, Miriam, Neumann, Sandra, Kaase, Martin, Gatermann, Soeren G. |
| Předmět: |
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| Zdroj: |
FEMS Microbiology Letters; Nov2011, Vol. 324 Issue 1, p48-55, 8p |
| Abstrakt: |
For several Staphylococci, such as S taphylococcus aureus, S taphylococcus saprophyticus, and S taphylococcus epidermidis, invasion of eukaryotic cells has been described and this mechanism has been considered an important part of the infection process. The fibrinogen-binding protein ( Fbl) of S taphylococcus lugdunensis, a homolog of the clumping factor A of S . aureus, has been described as fibrinogen-binding adhesin and might promote invasion of cells. We therefore characterized several clinical strains of S . lugdunensis in terms of whole cell fibrinogen and fibronectin binding and correlated these results with the invasion of epithelial and endothelial cells by S . lugdunensis. We described for the first time invasion of cells by S . lugdunensis. As invasion of cells by S . lugdunensis was only partly inhibited by cytochalasin D in contrast to a complete inhibition of invasion of cells by S . aureus, further invasion mechanisms are likely to be present in S . lugdunensis. In addition, the Fbl of S . lugdunensis is not involved in the invasion of cells as ruled out by an isogenic fbl mutant. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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