Cytochemical profile of B and T leukaemic lymphocytes with special reference to acute lymphoblastic leukaemia.

Autor: Catovsky, D., Galetto, J., Okos, A., Miliani, E., Galton, D. A. G.
Zdroj: Journal of Clinical Pathology; Oct1974, Vol. 27 Issue 10, p767-771, 5p, 2 Black and White Photographs, 2 Charts
Abstrakt: The PAS and acid phosphatase reactions showed a different pattern of positivity in the cells of lymphoproliferative disorders according to their B or T cell nature. In B-cell leukaemias (chronic lymphocytic and prolymphocytic) a low proportion of lymphocytes gave a positive result with the acid phosphatase reaction, while the majority were PAS positive in granular form. In contrast, in the T-prolymphocytic and T-lymphoblastic leukaemias the acid phosphatase reaction was positive in the majority of cells, while the PAS reaction was only positive in a minority. The significance of these findings, particularly for the recognition of a distinct T-cell variant of acute lymphoblastic leukaemia, is discussed. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index