Inhibition of secretin stimulated pancreatic secretion by pancreatic polypeptide.

Autor: Adrian, T E, Besterman, H S, Mallinson, C N, Greenberg, G R, Bloom, S R
Zdroj: Gut; Jan1979, Vol. 20 Issue 1, p37-40, 4p, 2 Charts, 2 Graphs
Abstrakt: The effect of PP on secretin-stimulated pancreatic secretion was assessed in five healthy subjects. During an intravenous infusion of BPP at a dose which produced plasma levels similar to those seen after meals in healthy young adults the volume and bicarbonate content of duodenal juice was reduced by 25% (p less than 0.05) and 24% (p less than 0.05) respectively, while protein and bilirubin concentrations were more markedly reduced by 68% (p less than 0.0005) and 67% (p less than 0.0005) respectively. PP, thus, may be an important inhibitory factor in the control of bilirubin and pancreatic enzyme secretion in man. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index