Carcinomatous meningitis: antibody-guided therapy with I-131 HMFG1.
| Autor: | Moseley, R P, Benjamin, J C, Ashpole, R D, Sullivan, N M, Bullimore, J A, Coakham, H B, Kemshead, J T |
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| Předmět: |
THERAPEUTIC use of monoclonal antibodies
IODINE radioisotopes COMPARATIVE studies GLYCOPROTEINS IMMUNITY LONGITUDINAL method RESEARCH methodology MEDICAL cooperation MENINGITIS NEUROLOGIC examination RADIONUCLIDE imaging RESEARCH TUMOR antigens MENINGES EVALUATION research MEMBRANE glycoproteins TUMORS THERAPEUTICS |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry; Mar1991, Vol. 54 Issue 3, p260-265, 6p |
| Abstrakt: | Seven patients with carcinomatous meningitis were administered intrathecal I-131 labelled monoclonal antibody HMFG1. Clinical responses were seen in two patients, with a long term survivor at 32 months. Aseptic meningitis occurred in 4/7 patients, but more serious toxicity was observed in the form of seizures (2/7 patients) and myelosuppression (3/7 patients). Partial obliteration of the subarachnoid space was identified as a potential problem in patients with advanced disease. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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