Oligoclonal "fingerprint" of CSF IgG in multiple sclerosis patients is not modified following intrathecal administration of natural beta-interferon.

Autor: Confavreux, C, Chapuis-Cellier, C, Arnaud, P, Robert, O, Aimard, G, Devic, M
Zdroj: Journal of Neurology, Neurosurgery & Psychiatry; Nov1986, Vol. 49 Issue 11, p1308-1312, 5p
Abstrakt: The IgG pattern in CSF was studied in 11 patients with multiple sclerosis who exhibited an oligoclonal banding upon thin-layer polyacrylamide gel isoelectric focusing followed by silver stain of unconcentrated CSF. Each patient received beta-interferon intrathecally during a 2 month period. No modification was observed over a 6 month period. In addition, the oligoclonal pattern was remarkably unique for each individual representing a typical "fingerprint" which allowed the identification of any single CSF. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index